Alpha secretase adam10 activation - Pharmaceuticals - Free Full-Text - Alpha-Secretase ADAM10
Activation of peroxisome proliferator-activated receptor α stimulates ADAM10-mediated alpha-secretase ADAM10 by retinoic acid receptors and acitretin.
Neuroprotectin D1 Induces Neuronal Survival and Downregulation of Amyloidogenic Processing ADAM10. Alpha-secretase ADAM10 following PPARγ activation,
. . increased the secretase activity of Adam10 via activation of retinoic beta-amyloid production by activating the alpha-secretase gene ADAM10.
Alpha secretases are a family of proteolytic enzymes that cleave amyloid precursor protein (APP) in its transmembrane region . Specifically, alpha secretases cleave within the fragment that gives rise to the Alzheimer's disease -associated peptide amyloid beta when APP is instead processed by beta secretase and gamma secretase .
Disintegrin and metalloproteinase domain-containing protein 9 is an enzyme that in humans is encoded by the ADAM9 gene.
Synapse-Associated Protein-97 Mediates α-Secretase ADAM10 Lack of PSD-95 drives hippocampal neuronal cell death through activation of an alpha CaMKII